A synthetic vaccine is a vaccine consisting mainly of synthetic peptides, carbohydrates, or antigens. They are usually considered to be safer than vaccines from bacterial cultures.
The world's first synthetic vaccine was created in 1982 from diphtheria toxin by Louis Chedid (scientist) from the Pasteur Institute and Michael Sela from the Weizmann Institute. In 1986, Manuel Elkin Patarroyo created the SPf66, the first version of a synthetic vaccine for Malaria.